LOUISVILLE, Ky. (AP) 鈥� The calls and emails started coming into and soon after doctors began experimenting with pig organs in humans.
People worried they鈥檒l never get a scarce human transplant asked: When could we ?
Alex Berrios of Louisville, Kentucky, needs a second transplant but finding another human match is proving impossible. So he's closely watching for a chance at pig kidney research.
"It may not work, and I have to be OK with that,鈥� Berrios said. 鈥淚 think it鈥檚 worth the shot.鈥�
Now two U.S. companies aim to begin the world鈥檚 first clinical trials of xenotransplantation in 2025 鈥� to try to save human lives. Would-be volunteers are impatient to see if they'll qualify as researchers fine-tune how best to test if the humanized pig organs they鈥檝e designed might really work.
Anticipation is growing with news that an Alabama woman was faring well after a pig kidney transplant at NYU in late November. Towana Looney is the fifth American to receive a gene-edited pig organ, each case so far an emergency experiment for people out of options.
None of the previous recipients 鈥� two given and 鈥� survived more than but that hasn't deterred researchers hunting an alternative to the dire shortage of transplantable organs.
鈥淲e have to have the courage to continue,鈥� said University of Maryland transplant surgeon Dr.
Patients are driving the quest for pig organ transplants
Back in 2022, Griffith had a hard time figuring out how to ask a dying patient if he鈥檇 consider undergoing the world鈥檚 first transplant of a gene-edited pig heart.
鈥淚 was so afraid to mention the word pig heart,鈥� Griffith said. He marveled that patient David Bennett responded with a joke about oinking and made clear if the failed that 鈥渕aybe you鈥檒l learn something for others like me.鈥�
Fast forward to late 2023, when patients at a National Kidney Foundation meeting with FDA officials and pig developers described a life so miserable on dialysis that they, too, would chance an animal organ.
鈥淲hy not try? That was really what we took back,鈥� said Mike Curtis, CEO of eGenesis, one of the companies developing organs. 鈥淚t was like we really almost have an obligation to try.鈥�
鈥淭he patients pushed us to go ahead,鈥� agreed Dr. Tatsuo Kawai, a Mass General surgeon who鈥檇 been reluctant to even broach the idea 鈥� but last March, four months after that meeting, gave a longtime patient the first gene-edited pig kidney.
Sick and tired from dialysis, patients raise their hands for pig kidneys
In Palm Springs, California, Carl McNew emailed NYU to ask about volunteering while he鈥檚 still fairly healthy.
McNew donated a kidney to his husband in 2015 but later his remaining kidney began declining, something very rare in living donors. Medications and intermittent dialysis are helping but McNew knows he鈥檒l eventually need a transplant.
鈥淭here鈥檚 just something about being part of something like that, that is so cutting-edge,鈥� said McNew, who spotted news of NYU鈥檚 xenotransplant research in 2023 and emailed his interest.
For Louisville鈥檚 Berrios, donor scarcity isn鈥檛 the only hurdle. Born with a single kidney that failed in his late 20s, a living donor transplant restored his health for 13 years. But it failed in 2020 and he has since developed antibodies that would destroy another human kidney, what doctors call 鈥渉ighly sensitized.鈥�
Every Monday, Wednesday and Friday, Berrios quietly slips out of his home before dawn to spend nearly four hours tethered to a dialysis machine. Getting the grueling treatments at 5 a.m. is the only way the father of two can both stay alive and hold down a fulltime job.
But dialysis doesn鈥檛 fully replace kidney function 鈥� people slowly get sicker. So even as Berrios tried an experimental therapy to tamp down his problem antibodies, he told NYU he's interested in a pig kidney.
Expected soon: Rigorous trials testing pig organ transplants
FDA rules require that pig organs be extensively tested in monkeys or baboons before humans. And while researchers have extended those primates鈥� survival to a year, sometimes longer, they were desperate for experience with people. After all, the pig organs are genetically altered to be more humanlike, not more baboon-like.
At NYU and , surgeons first tested pig organs in bodies of the donated for scientific research.
And patients given pig organs so far have been 鈥渃ompassionate use鈥� transplants, experiments that FDA allows in select emergency cases for people out of other options.
Although the first four didn鈥檛 survive long, in part because of complications from other diseases, those experiments proved pig organs could work at least for a while and offered other lessons. For example, discovery of a hidden pig virus in the first heart transplant prompted better tests for that risk.
Only rigorous studies comparing similarly ill patients will offer a clearer picture of pig organs鈥� potential 鈥� maybe those like Looney. Despite eight years of dialysis, she wasn鈥檛 nearly as sick as prior xenotransplant recipients but couldn鈥檛 find a matching donor. Like Berrios, she had a highly sensitized immune response.
Looney may be 鈥渒ind of a litmus test鈥� for trial candidates, said NYU鈥檚 Montgomery, who led her transplant with her original surgeon in Alabama, Dr. Jayme Locke. 鈥淪he鈥檚 received the transplant at just the right time,鈥� before dialysis did too much damage.
What gene edits produced the best pig organs for human transplant?
Scientists have tried animal-to-human transplants for years without success but now they can edit pig genes, trying to bridge the species gap enough to keep the human immune system from immediately attacking the foreign tissue. Still, nobody knows the best gene combination.
Revivicor, a United Therapeutics subsidiary, produces kidneys and hearts with 10 gene edits, 鈥渒nocking out鈥� pig genes that trigger hyper-rejection and excessive organ growth and adding some human genes to improve compatibility. Maryland used hearts with 10 gene edits in its two xenotransplants. Looney also got a kidney with 10 gene edits, based on Locke鈥檚 research when she worked in Alabama.
While Montgomery is thrilled with Looney鈥檚 progress, he's done most work using Revivicor pigs with just , in a xenotransplant last April and in research with the deceased.
鈥淥ur feeling is, you know, less is more,鈥� said Montgomery, noting it鈥檚 easier to mass produce pigs with fewer gene alterations. Looney鈥檚 transplant offers a chance to compare 鈥渞eally how much difference those additional gene edits are making.鈥�
In Boston, eGenesis has still another approach 鈥� a whopping 69 gene edits. In addition to 10 genetic alterations to improve human compatibility, genes linked to certain pig viruses also are inactivated.
Pig organ transplants still have much to prove
Researchers feel pressure to show if pig organs can keep people alive much longer than a few months, said eGenesis' Curtis. If not, the question will be 鈥渄o we have the right gene edits?鈥�
The balance is choosing participants sick enough to qualify but not so sick they have no chance.
鈥淭here鈥檚 a tremendous number of patients who would be very willing, very willing to do this,鈥� said Dr. Silke Niederhaus of the University of Maryland, who isn鈥檛 involved in xenotransplant research but watches it closely.
Niederhaus became a kidney transplant surgeon because around her 12th birthday, one saved her life. That kidney lasted three decades. When it failed, it took five years to find another. So she understands the draw of pig research, and urges people to learn their odds of getting a human kidney before volunteering.
If they鈥檙e younger, healthier or have a living donor, 鈥淚 would probably say go with what鈥檚 known and what鈥檚 proven,鈥� Niederhaus said. But if they鈥檙e older and dialysis is starting to fail, 鈥渕aybe it鈥檚 worth taking the risk.鈥�
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AP video journalist Shelby Lum contributed to this story.
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Lauran Neergaard, The Associated Press
